Presentation
Research description
The glycocalyx is a complex, carbohydrate-rich layer covering the surface of nearly all living cells. It consists of glycoproteins, proteoglycans, and glycolipids and plays a crucial role in regulating interactions between cells and their surrounding environment. The carbohydrate structures, known as glycans, are involved in numerous biological processes, including cell communication, immune recognition, and interactions between pathogens and host cells.
My research focuses on engineering artificial glycomaterials to investigate how glycan composition, spatial organization, and material properties influence molecular recognition at biological interfaces, and to develop strategies for selectively controlling glycan-mediated interactions with proteins, viruses, and cells.
Research directions
Glycan-mediated molecular recognition and functional nanomaterials
We develop glycan-functionalized surfaces, nanoparticles, and polymer-based hydrogels to investigate how glycan composition, density, ligand mobility, and material flexibility influence multivalent interactions with proteins and viruses. These studies contribute to the development of biomimetic interfaces for antiviral applications and the selective detection and differentiation of viruses.
Live-cell glycocalyx editing
We engineer functional polymer capsules using layer-by-layer (LbL) assembly for the controlled delivery of bioactive agents that modify the cellular glycocalyx. This approach aims to control glycan presentation and molecular interactions at the surface of living cells, with potential applications in selective cell targeting and cancer therapy. Our research investigates how capsule composition and architecture influence the encapsulation, protection, and controlled release of these agents while preserving their biological activity.
Research aim
Our research aims to control molecular interactions at biological interfaces by engineering biomaterials with tailored chemical composition, spatial organization, and physical properties for applications in diagnostics, disease prevention, and therapeutic delivery.
